State: New York

Funded by Marketing Research Consultants
In honor of Gil Hatch

Funded by the Spirit of Jimmy V Gala
In honor of Coach Jim Boeheim

Funded by the UNICO Foundation
In memory of Richard Juliano

Funded by the Spirit of Jimmy V New York Gala
In honor of Rudolph W. Giuliani

Funded by the Dick Vitale Gala in memory of Eddie Livingston

Anti-GD2 monoclonal antibodies are now standard of care for patients with high-risk neuroblastoma, but there is little information on their biodistribution and tumor targeting in patients. We are developing a third generation anti-GD2 MoAb humanized 3F8 (hu3F8) for therapy of neuroblastoma. This proposed study will use a small dose of radioactive hu3F8 to determine its distribution and targeting using PET imaging which can provide sophisticated and quantitative data. This information will be critical in refining current dosing regimens for hu3F8 and improve the design of future clinical studies. Moreover, if specific tumor targeting can be demonstrated, as study of radioactive hu3F8 for therapy of patients with poor-prognosis neuroblastoma will be initiated.